Design Principles for Therapuetic Text Message Interventions

A peer-reviewed research article, published on PubMed, analyzed the efficacy of 9 text message interventions across 8 studies to determine which approaches yielded the most favorable results.


The authors of the study, Finitsis et al., sought to determine the effectiveness of text-messaging interventions to promote adherence to antiretroviral therapy given: 

  1. the failure of many patients to adhere at high enough rates to maintain health and reduce the risk of transmission, and
  2. the global growth of mobile phone use. 


The paper, Text Message Intervention Designs to Promote Adherence to AntiRetroviral Therapy (ART): A Meta-Analysis of Randomized Controlled Trials, complied and analyzed studies that: 

  1. targeted antiretroviral therapy adherence in a sample of people living with HIV, 
  2. used a randomized-controlled trial design to examine a text messaging intervention, and 
  3. reported at least one adherence measurement or clinical outcome.


Their analyses found that interventions are most successful when: 

  1. they were sent less frequently than daily,
  2. they supported bidirectional communication
  3. included personalized message content, and
  4. were matched to participants' treatment schedules.

Applying these Principles

These principles not only highlight best practices in mobile intervention design, but TextIt's core functionality as well. Our campaigns feature, a product of our participation in a study conducted by Odeny et al., enables anyone to apply these principles using TextIt, while our array of channel options allows for instant deployment at any scale. 

Send us a note at to learn more, or sign-up for a free account to put these principles to action.